TMOD-23. DYNAMIC PATTERNS OF GLIOBLASTOMA CLONAL EVOLUTION IN RESPONSE TO CHEMORADIOTHERAPY

Abstract Despite aggressive multimodal therapy, glioblastoma (GBM) remains incurable and inevitably relapses. Recent data have implicated intratumoral heterogeneity as the driver of therapy resistance and tumour relapse in GBM. Models that capture the evolution of GBM biology in response to standard-of-care (SoC) chemoradiotherapy will allow for the identification of cellular mechanisms that govern GBM therapy failure. In this study, we coupled …