Journal article
Abstract 5041: TEM-1 targeted alpha therapeutic [Ac-225]-FPI-1848 induces regression in pre-clinical sarcoma xenograft models
Abstract
Abstract
Background: Tumor endothelial marker 1 (TEM-1 or CD248) is a cell surface receptor belonging to a family of C-type lectin transmembrane proteins. Identified as a fetal antigen, expression peaks during embryogenesis but is minimally detected in adulthood. In pathological conditions TEM-1 has been shown to be overexpressed in cancer and fibrosis. In sarcomas, expression occurs throughout the tumor environment in …
Authors
Collens S; Robinson N; Moran M; Simms R; Storozhuk Y; Hu M; Grinshtein N; Forbes J; Leamon CP; Valliant J
Journal
Cancer Research, Vol. 83, No. 7_Supplement, pp. 5041–5041
Publisher
American Association for Cancer Research (AACR)
Publication Date
April 4, 2023
DOI
10.1158/1538-7445.am2023-5041
ISSN
0008-5472