Journal article
Expansion of Primary Human AML by Aryl Hydrocarbon Receptor Antagonism Minimally Affects Leukemic Transcriptional Profiles but Alters Cellular Metabolism
Abstract
Small molecule-based antagonism of the aryl hydrocarbon receptor (AHR) by StemRegenin1 (SR1) promotes ex vivo expansion and maintenance of primary human hematopoietic stem cells (HSCs) as well as acute myeloid leukemia (AML) cells. However, basis and nature of SR1 induced expansion of human AML remains unknown. Here, global expression profiling on 7 clinically diverse human AML patient samples treated ex vivo with a synthesized analog of SR1 …
Authors
Casado FL; Salci KR; Shapovalova Z; Guezguez B; Collins TJ; Bhatia M
Journal
Journal of Hematology Research, Vol. 2, No. 1, pp. 9–16
Publisher
Savvy Science Publisher
DOI
10.12974/2312-5411.2015.02.01.2
ISSN
2312-5411