Journal article
A139 A LOW FODMAP DIET REDUCES SYMPTOMS IN INDIVIDUAL IBS PATIENTS BUT NOT MUCOSAL IMMUNE ACTIVATION OF NOCICEPTORS
Abstract
Lowering dietary FODMAPs in IBS patients reduces symptom severity in many cases yet the mechanism is poorly understood. It has been proposed that FODMAPs may activate mast cells in some patients. Mast cell mediators in turn could sensitize nociceptors innervating the gut, leading to exaggerated pain signalling. To determine if altering FODMAP intake modulates the excitability of nociceptors. Three IBS patients (Rome IV; 12 wk longitudinal …
Authors
Bennet SM; Tuck CJ; Jiménez-Vargas NN; Lopez CDL; Polanco JOJ; Morissette C; Rolland S; Bercik P; Reed DE; Vanner S
Journal
Journal of the Canadian Association of Gastroenterology, Vol. 2, No. Supplement_2, pp. 277–278
Publisher
Oxford University Press (OUP)
Publication Date
March 15, 2019
DOI
10.1093/jcag/gwz006.138
ISSN
2515-2084