A46 FECAL β-DEFENSIN LEVELS AS A RELIABLE BIOMARKER OF INTESTINAL DYSBIOSIS

Dysbiosis is defined as alterations or instability in gut microbial composition resulting in altered host function. It is triggered by many environmental factors and has been implicated in the pathogenesis of the Irritable Bowel Syndrome (IBS). Recent focus on the putative role of intestinal microbiome generating low grade inflammation and immune activation in IBS has increased the need for a marker of dysbiosis. β-defensins (β-def) are …