This chapter presents a clinical scenario of a 65‐year‐old man who had complains of progressive curling of his ring and little fingers, and inability to straighten his fingers. There is no consensus on the most effective treatment for Dupuytren’s disease (DD). Currently, the two most common treatments for DD are partial palmar fasciectomy and collagenase injection. Percutaneous needle fasciotomy (PNF) is another commonly performed treatment for DD, and involves division of the diseased cords with a hypodermic needle. The patient should be counseled that treatment with fasciectomy has a lower recurrence rate than PNF. If they prefer a less invasive treatment, there is no significant difference in recurrence rates between PNF and collagenase injection. The chapter also provides recommendations for implementing evidence‐based practice in the clinical setting.