Journal article
Granzyme K contributes to endothelial microvascular damage and leakage during skin inflammation
Abstract
BACKGROUND: Granzyme K (GzmK) is a serine protease with minimal presence in healthy tissues while abundant in inflamed tissues. Initially thought to play an exclusive role in immune-mediated cell death, extracellular GzmK can also promote inflammation.
OBJECTIVES: To evaluate the role of GzmK in the pathogenesis of atopic dermatitis (AD), the most common inflammatory skin disease.
Authors
Turner CT; Zeglinski MR; Boivin W; Zhao H; Pawluk MA; Richardson KC; Chandrabalan A; Bird P; Ramachandran R; Sehmi R
Journal
British Journal of Dermatology, Vol. 189, No. 3, pp. 279–291
Publisher
Oxford University Press (OUP)
Publication Date
August 24, 2023
DOI
10.1093/bjd/ljac017
ISSN
0007-0963