Journal article
First-in-human imaging using [11C]MDTC: a radiotracer targeting the cannabinoid receptor type 2
Abstract
PurposeWe report findings from the first-in-human study of [11C]MDTC, a radiotracer developed to image the cannabinoid receptor type 2 (CB2R) with positron emission tomography (PET).MethodsTen healthy adults were imaged according to a 90-min dynamic PET protocol after bolus intravenous injection of [11C]MDTC. Five participants also completed a second [11C]MDTC PET scan to assess test-retest reproducibility of receptor-binding outcomes. The …
Authors
Du Y; Coughlin JM; Brosnan MK; Chen A; Shinehouse LK; Abdallah R; Lodge MA; Mathews WB; Liu C; Wu Y
Journal
European Journal of Nuclear Medicine and Molecular Imaging, Vol. 50, No. 8, pp. 2386–2393
Publisher
Springer Nature
Publication Date
July 2023
DOI
10.1007/s00259-023-06170-y
ISSN
1619-7070