Highly Stereoselective and General Synthesis of (E)‐Stilbenes and Alkenes by Means of an Aqueous Wittig Reaction Journal Articles uri icon

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abstract

  • AbstractThe chemoselective formation of trialkyl(benzylidene) ylides in water and their Wittig reaction with aromatic and aliphatic aldehydes provides a practical, stereoselective and environmentally benign route to valuable (E)‐stilbenes and alkenes. The synthesis of the phytoalexin resveratrol is described. In addition, the method allows for a gram‐scale synthesis of the anticancer agent DMU‐212 utilizing no organic solvent at any stage. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

publication date

  • August 2009