Journal article
Development of a one-pot method for the homologation of aldehydes to carboxylic acids
Abstract
A highly efficient method is described for the one-carbon homologation of aldehydes to carboxylic acid derivatives employing the reaction of a 1,1-bis-dimethylphosphonate derivative with the aldehyde and controlled acid hydrolysis of the derived α-phosphonoenamine intermediate.
Authors
McNulty J; Das P
Journal
Tetrahedron, Vol. 65, No. 37, pp. 7794–7800
Publisher
Elsevier
Publication Date
September 2009
DOI
10.1016/j.tet.2009.07.032
ISSN
0040-4020