Discovery of a Robust and Efficient Homogeneous Silver(I) Catalyst for the Cycloaddition of Azides onto Terminal Alkynes

Abstract A highly efficient, chemically stable, and well‐defined homogeneous silver(I) catalyst is reported for the cycloaddition of azides onto terminal alkynes (Ag‐AAC reaction). The Ag‐AAC reaction occurs at room temperature or with heating to deliver exclusively the corresponding 1,4‐triazole. A pronounced ligand effect was discovered through systematic modification to the ligand structure resulting in the discovery of a chemically stable active catalyst for this reaction.