Multilevel computations of dispersed drug release Journal Articles

abstract

• AbstractWe study a mathematical model of drug release from controlled delivery systems with initial drug loading higher than solubility. The model combines dissolution, diffusion, swelling, and erosion mechanisms of drug delivery. Multilevel methods are introduced to solve the governing system of diffusion equations numerically with better accuracy and lower computational costs compared with the finite element methods. Numerical examples are given to demonstrate the advantages of the multilevel methods. Numerical solutions are compared to exact and approximate solutions of the reduced models. © 2012 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq, 2013

authors

• Zhao, Wei
• Pelinovsky, Dmitry E

status

• published 

publication date

• July 2013

has subject area

• 0102 Applied Mathematics (FoR)
• 0103 Numerical and Computational Mathematics (FoR)
• Numerical & Computational Mathematics (Science Metrix)

published in

• Numerical Methods for Partial Differential Equations  Journal

keywords

• BOUNDARY-VALUE-PROBLEMS
• DIFFUSIONAL RELEASE
• FINITE-ELEMENT
• LAYER
• Mathematics
• Mathematics, Applied
• POLYMER MATRIX
• Physical Sciences
• SOLUTE
• Science & Technology
• controlled drug release
• mathematical modeling
• multilevel scheme
• system of diffusion equations

Digital Object Identifier (DOI)

• 10.1002/num.21761

start page

• 1391

end page

• 1415

volume

• 29

issue

• 4