The synthesis and high-resolution NMR spectroscopy of ethyl N-(2-triphenylmethylthio)ethanoyl-O-{4′-[4″-(1″-bis(2″′-chloroethyl)amino)phenyl]butanoyl}-<scp>L</scp>-seryl-S-benzyl-<scp>L</scp>-cysteine: a chelate–chlorambucil complex for use as a ligand for 99mTc radio-imaging

A potential agent for the imaging of tumours has been synthesized from the antineoplastic agent chlorambucil. Standard peptide coupling techniques were used to synthesize a tripeptide covalently coupled to chlorambucil in 10 steps. The final product was characterized by high-resolution NMR spectroscopy. Key words: ethyl N-triphenylmethylthioethanoyl-O-{4′-[4″-(1"-bis(2″′-chloroethyl)amino)phenyl]butanoyl}-L-seryl-S-benzyl-L-cysteine, NMR spectroscopy, synthesis, radio-imaging agent.

COSY
Chemistry
Chemistry, Multidisciplinary
NMR spectroscopy
PULSED FIELD GRADIENTS
Physical Sciences
SELECTION
SPECTRA
Science & Technology
TECHNETIUM
ethyl N-triphenylmethylthioethanoyl-O-{4'-[4''-(1''-bis(2'''-chloroethyl)amino)phenyl]butanoyl}-L-seryl-S-benzyl-L-cysteine
radio-imaging agent
synthesis

The synthesis and high-resolution NMR spectroscopy of ethyl N-(2-triphenylmethylthio)ethanoyl-O-{4′-[4″-(1″-bis(2″′-chloroethyl)amino)phenyl]butanoyl}-L-seryl-S-benzyl-L-cysteine: a chelate–chlorambucil complex for use as a ligand for ^99mTc radio-imaging Journal Articles