The synthesis and high-resolution NMR spectroscopy of ethyl N-(2-triphenylmethylthio)ethanoyl-O-{4′-[4″-(1″-bis(2″′-chloroethyl)amino)phenyl]butanoyl}-L-seryl-S-benzyl-L-cysteine: a chelate–chlorambucil complex for use as a ligand for 99mTc radio-imaging Academic Article uri icon

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abstract

  • A potential agent for the imaging of tumours has been synthesized from the antineoplastic agent chlorambucil. Standard peptide coupling techniques were used to synthesize a tripeptide covalently coupled to chlorambucil in 10 steps. The final product was characterized by high-resolution NMR spectroscopy. Key words: ethyl N-triphenylmethylthioethanoyl-O-{4′-[4″-(1"-bis(2″′-chloroethyl)amino)phenyl]butanoyl}-L-seryl-S-benzyl-L-cysteine, NMR spectroscopy, synthesis, radio-imaging agent.

publication date

  • August 1, 1996