The synthesis of corticosteroid–carborane esters for the treatment of rheumatoid arthritis via boron neutron capture synovectomy

Two corticosteroid–carborane esters were synthesized through the use of a BOP-Cl promoted esterification. The steroid–carborane conjugates are designed to selectively deliver boron to arthritic tissue for boron neutron capture synovectomy, a new therapeutic approach for rheumatoid arthritis.