Journal article
Human melatonin MT1 receptor induction by valproic acid and its effects in combination with melatonin on MCF-7 breast cancer cell proliferation
Abstract
We have reported that valproic acid upregulates melatonin MT1 receptor expression in rat C6 glioma cells. In addition to its anticonvulsant and mood stabilizing properties, valproic acid can also inhibit the growth of cancer cells. Since the melatonin MT1 receptor has been implicated in the oncostatic action of melatonin on human MCF-7 breast cancer cells, the effect of valproic acid on its expression was examined in this cell line. Treatment …
Authors
Jawed S; Kim B; Ottenhof T; Brown GM; Werstiuk ES; Niles LP
Journal
European Journal of Pharmacology, Vol. 560, No. 1, pp. 17–22
Publisher
Elsevier
Publication Date
March 2007
DOI
10.1016/j.ejphar.2007.01.022
ISSN
0014-2999