Journal article
MPP+-induced cytotoxicity in neuroblastoma cells: Antagonism and reversal by guanosine
Abstract
Guanosine exerts neuroprotective effects in the central nervous system. Apoptosis, a morphological form of programmed cell death, is implicated in the pathophysiology of Parkinson’s disease (PD). MPP+, a dopaminergic neurotoxin, produces in vivo and in vitro cellular changes characteristic of PD, such as cytotoxicity, resulting in apoptosis. Undifferentiated human SH-SY5Y neuroblastoma cells had been used as an in vitro model of Parkinson’s …
Authors
Pettifer KM; Jiang S; Bau C; Ballerini P; D’Alimonte I; Werstiuk ES; Rathbone MP
Journal
Purinergic Signalling, Vol. 3, No. 4, pp. 399–409
Publisher
Springer Nature
Publication Date
September 2007
DOI
10.1007/s11302-007-9073-z
ISSN
1573-9538