Journal article
Guanosine stimulates neurite outgrowth in PC12 cells via activation of heme oxygenase and cyclic GMP
Abstract
Undifferentiated rat pheochromocytoma (PC12) cells extend neurites when cultured in the presence of nerve growth factor (NGF). Extracellular guanosine synergistically enhances NGF-dependent neurite outgrowth. We investigated the mechanism by which guanosine enhances NGF-dependent neurite outgrowth. Guanosine administration to PC12 cells significantly increased guanosine 3-5-cyclic monophosphate (cGMP) within the first 24 h whereas addition of …
Authors
Bau C; Middlemiss PJ; Hindley S; Jiang S; Ciccarelli R; Caciagli F; DiIorio P; Werstiuk ES; Rathbone MP
Journal
Purinergic Signalling, Vol. 1, No. 2, pp. 161–172
Publisher
Springer Nature
Publication Date
6 2005
DOI
10.1007/s11302-005-6214-0
ISSN
1573-9538