Construction and structure studies of DNA-bipyridine complexes as versatile scaffolds for site-specific incorporation of metal ions into DNA Academic Article uri icon

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  • The facile construction of metal-DNA complexes using 'Click' reactions is reported here. A series of 2'-propargyl-modified DNA oligonucleotides were initially synthesized as structure scaffolds and were then modified through 'Click' reaction to incorporate a bipyridine ligand equipped with an azido group. These metal chelating ligands can be placed in the DNA context in site-specific fashion to provide versatile templates for binding various metal ions, which are exchangeable using a simple EDTA washing-and-filtration step. The constructed metal-DNA complexes were found to be thermally stable. Their structures were explored by solving a crystal structure of a propargyl-modified DNA duplex and installing the bipyridine ligands by molecular modeling and simulation. These metal-DNA complexes could have wide applications as novel organometallic catalysts, artificial ribonucleases, and potential metal delivery systems.


  • Wang, Rui
  • Ranganathan, Srivathsan V
  • Haruehanroengra, Phensinee
  • Mao, Song
  • Scalabrin, Matteo
  • Fabris, Daniele
  • Chen, Alan
  • Liu, Hehua
  • Hassan, Abdalla EA
  • Gan, Jianhua
  • Sheng, Jia

publication date

  • February 11, 2019