Journal article
Monoclonal antibodies against Epstein-Barr virus cross-react with alpha-synuclein in human brain.
Abstract
Using antibodies generated against the latent membrane protein 1 of Epstein-Barr virus, intense immunoreactivity of Lewy bodies (in PD and dementia with Lewy bodies) and glial cytoplasmic inclusions (in multiple system atrophy) was demonstrated. ELISA and Western blotting techniques confirmed that this immunolabeling was due to cross-reactivity of the antiviral antibody with alpha-synuclein, a neuronal protein implicated in the pathogenesis of …
Authors
Woulfe J; Hoogendoorn H; Tarnopolsky M; Muñoz DG
Journal
Neurology, Vol. 55, No. 9, pp. 1398–1401
Publisher
Wolters Kluwer
Publication Date
November 14, 2000
DOI
10.1212/wnl.55.9.1398
ISSN
0028-3878