Journal article
Metabolite measurements in the caudate nucleus, anterior cingulate cortex and hippocampus among patients with mitochondrial disorders: a case–control study using proton magnetic resonance spectroscopy
Abstract
BACKGROUND: Mitochondrial disorders are clinical syndromes associated with mutations in the mitochondrial or nuclear genome that result in impaired oxidative phosphorylation and deficient energy production. Metabolic abnormalities in brain areas associated with cognitive functions could give rise to neuropsychiatric symptomatology. The aim of this study was to use single-voxel proton magnetic resonance spectroscopy to identify metabolic …
Authors
Anglin RE; Rosebush PI; Noseworthy MD; Tarnopolsky M; Weber AM; Soreni N; Mazurek MF
Journal
CMAJ Open, Vol. 1, No. 1, pp. e48–e55
Publisher
Joule
Publication Date
April 26, 2013
DOI
10.9778/cmajo.20120020
ISSN
2291-0026