Spectrally resolved bioluminescence optical tomography Academic Article uri icon

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abstract

  • Spectrally resolved bioluminescence optical tomography is an approach to recover images of luciferase activity within a volume using multiwavelength emission data from internal bioluminescence sources. The underlying problem of uniqueness associated with nonspectrally resolved intensity-based bioluminescence tomography is highlighted. Reconstructed images of bioluminescence are presented by using as input both simulated and real multiwavelength data from a tissue-simulating phantom. The location of the internal bioluminescence is obtained with 1 mm accuracy. Further, the amplitude of the reconstructed source is proportional to the actual bioluminescence intensity.

authors

  • Dehghani, Hamid
  • Davis, Scott C
  • Jiang, Shudong
  • Pogue, Brian W
  • Paulsen, Keith D
  • Patterson, Michael

publication date

  • 2006