Journal article
A dynamic model for ALA-PDT of skin: simulation of temporal and spatial distributions of ground-state oxygen, photosensitizer and singlet oxygen
Abstract
Singlet oxygen (¹O₂) direct dosimetry and photosensitizer fluorescence photobleaching are being investigated and applied as dosimetric tools during 5-aminolevulinic acid (ALA)-induced protophorphyrin IX (PpIX) photodynamic therapy (PDT) of normal skin and skin cancers. The correlations of photosensitizer fluorescence and singlet oxygen luminescence (SOL) emission signals to ¹O2 distribution and cumulative ¹O₂dose are difficult to interpret …
Authors
Liu B; Farrell TJ; Patterson MS
Journal
Physics in Medicine and Biology, Vol. 55, No. 19, pp. 5913–5932
Publisher
IOP Publishing
Publication Date
October 7, 2010
DOI
10.1088/0031-9155/55/19/019
ISSN
0031-9155