Journal article
A behavioral profile of autoimmune lupus-prone MRL mice
Abstract
Manifestations of the human autoimmune disease systemic lupus erythematosus (SLE) include a number of behavioral and cognitive deficits. The present study asks whether neurobehavioral dysfunction is present also in MRL mice that spontaneously develop most of the fundamental immunological aberrations of SLE. There are two congenic substrains of MRL mice that differ in the time of disease onset: MRL-lpr mice develop lupus early and MRL(-)+/+ …
Authors
Šakić B; Szechtman H; Keffer M; Talangbayan H; Stead R; Denburg JA
Journal
Brain Behavior and Immunity, Vol. 6, No. 3, pp. 265–285
Publisher
Elsevier
Publication Date
September 1992
DOI
10.1016/0889-1591(92)90048-s
ISSN
0889-1591