Journal article
A switch mechanism between locomotion and mouthing implicated in sensitization to quinpirole in rats
Abstract
Abstract Rationale: Chronic treatment with the monoamine oxidase inhibitor (MAOI) clorgyline, blocks locomotor sensitization to the D2/D3 dopamine agonist quinpirole. It is unknown whether this blockade occurs via inhibition of the MAO enzyme or by another mechanism. Objectives: While clorgyline and moclobemide are equally effective MAOIs, only clorgyline has a high affinity for the MAOI-displaceable quinpirole binding site (MQB). This study …
Authors
Culver KE; Rosenfeld JM; Szechtman H
Journal
Psychopharmacology, Vol. 151, No. 2-3, pp. 202–210
Publisher
Springer Nature
Publication Date
8 2000
DOI
10.1007/s002139900346
ISSN
0033-3158