The burden of red blood cell transfusions in patients with lower-risk myelodysplastic syndromes and ring sideroblasts: an analysis of the prospective MDS-CAN registry Journal Articles uri icon

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  • Many patients with lower-risk myelodysplastic syndromes (LR MDS) require long-term red blood cell (RBC) transfusions to manage anemia. The consequences of RBC transfusions in LR MDS with ring sideroblasts (LR MDS-RS) are not well known. We estimated the association between cumulative RBC dose density and clinical and patient-reported outcomes using data from the MDS-CAN registry for patients enrolled between January 2008 and December 2018. Outcomes included overall survival, hospitalization, and health-related quality of life (HRQoL). A total of 145 enrolled patients with LR MDS and RS ≥5% had a median follow-up time of 27.1 months; 45 had no transfusions during follow-up, 51 had <1 transfusion per month, and 49 had ≥1 transfusion per month. The cumulative density of RBC transfusions was associated with significantly greater mortality, hospitalization, and inferior HRQoL, suggesting that exposure to RBC transfusion may constitute a significant treatment burden in patients with LR MDS-RS.


  • Buckstein, Rena
  • Chodirker, Lisa
  • Yee, Karen WL
  • Geddes, Michelle
  • Leitch, Heather A
  • Christou, Grace
  • Banerji, Versha
  • Leber, Brian
  • Khalaf, Dina
  • St-Hilaire, Eve
  • Finn, Nicholas
  • Nevill, Thomas
  • Keating, Mary-Margaret
  • Storring, John
  • Parmentier, Anne
  • Thambipillai, Aksharh
  • Tang, Derek
  • Westcott, Christopher
  • Cameron, Chris
  • Spin, Paul

publication date

  • February 23, 2023