Journal article
Abstract 641: Interleukin-15 Plays a Role in Atherosclerosis Through Effects on Multiple Inflammatory Cells in ApoE-/- Mice
Abstract
Objective: Interleukin (IL)-15 is a pro-inflammatory cytokine which is essential for the survival and maturation of natural killer (NK) and CD8+ T cells and has recently been reported to directly activate macrophages. In the present study, we used IL-15 overexpressing and IL-15 knockout mice to determine its effect on atherosclerosis in apolipoprotein E knockout (apoE-/-) mice. Approach and Results: Deficiency of IL-15 reduced atherosclerosis …
Authors
Dadoo O; Ashkar A; Richards C; Trigatti B
Journal
Arteriosclerosis Thrombosis and Vascular Biology, Vol. 34, No. suppl_1,
Publisher
Wolters Kluwer
Publication Date
May 2014
DOI
10.1161/atvb.34.suppl_1.641
ISSN
1079-5642