Behavioural rhythmicity in transgenic growth hormone mice: trade-offs, energetics, and sleepwake cycles

Transgenic mice with extra rat growth hormone (GH) genes (TRrGH mice) are behaviourally lethargic and sleep 3.4 h/d longer than normal on standard diets. We tested the hypothesis that the doubling of the growth rate of TRrGH mice reduced the energy available for behaviour. Provision of sucrose supplements ad libitum normalized the durations of activity and sleep. Our results support a new allocative theory suggesting that sleep serves as an …