Estrogen Metabolism and Prostate Cancer Risk: A Prospective Study

Prostate cancer is the most common cancer among men in the United States (IARC, 1995) and the second most common in the European Community (IARC, 1995). The causes of prostate cancer, however, remain largely unknown, with age, race, and family history being the only established risk factors (Nomura et al., 1997). The prostate gland has historically been considered the prototype of an androgen-dependent organ. However, there is evidence that …