Abstract 647: Hyperglycemia Increases Diet-Induced Coronary Artery Disease and Myocardial Infarction in SRBI Knockout ApoE-Hypomorphic Mice

Background: Type I diabetes is characterized by high levels of glucose and free fatty acids in plasma. Several epidemiological studies have established diabetes as an independent risk factor for the development of cardiovascular disease. Diabetic animal models have shown increased development of aortic atherosclerosis, however the impact on coronary artery (CA) disease is less clear. Conventional mouse models of atherosclerosis do not …