ER Stress‐Induced SREBP‐2 Activation Contributes to Lipid Accumulation in Tubular Nephrotoxicity

Disruption of protein folding in the endoplasmic reticulum (ER) leads to ER stress and activation of the unfolded protein response (UPR). Tubular damage caused by nephrotoxic drugs is associated with ER stress. Since ER stress is known to induce lipid dysregulation through the activation of sterol regulatory element binding proteins (SREBPs), we hypothesized that lipid accumulation observed in proximal tubules affected by nephrotoxic drugs is a …