Synthesis of [ 18 F]XeF 2 , a novel agent for the preparation of 18 F-radiopharmaceuticals

[18F]XeF2 was synthesised by isotopic exchange between XeF2 and anhydrous reactor-produced [18F]HF, [18F]SiF4, and [18F]AsF5 with a radiochemical yield of 30%; [18F]XeF2 may facilitate the direct radiofluorination of organic tracer molecules for positron emission tomography.