abstract
- Missing tissue compensators are used to improve dose uniformity for some patients undergoing radiation therapy. Currently, our practice is to machine compensators out of lead alloy plate. Replacing this physical filter with a segmented multileaf collimator (MLC) delivery sequence is beneficial in terms of work flow and delivery efficiency. The purpose of this work is to compare the dose uniformity achieved by fields that are either (A) conventionally compensated, compensated by segmenting the physical compensator thickness map into either (B) step-and-shoot or (C) dynamic MLC delivery sequences using an in-house sequencer, (D) compensated using Pinnacle sequencer, or (E) compensated using IMRT optimization. A computer program was developed to construct both step-and-shoot and dynamic MLC sequence files from mechanical thickness maps of our current compensators. In addition, the Pinnacle sequencer and IMRT optimization were used to generate step-and-shoot MLC sequences. Planar doses were measured for each at the isocenter depth with an ion chamber array to compare the five methods. A comparison of the relative dose distribution shows that the compensation achieved by method (E) is in close agreement with that achieved using method (A), that is, dose uniformity within 4%. Method (D) resulted in the shortest delivery time and achieved dose uniformity to within 5%. Methods (B) and (C) need additional refinement to be of practical use. The results support the feasibility of replacing physical compensators with MLC delivery sequences. Compensation by MLC segments provides more flexibility and efficiency in design and delivery than by physical compensators while maintaining or improving the uniformity of dose to the plane of compensation.