The adenovirus e1a-associated p300 protein is differentially phosphorylated in ad12 e1a-compared to ad5 e1a-transformed rat-cells.

Recently, using hybrid Ad5/12 E1A-transformed rat cells, we identified at least two regions of Ad12 E1A which influence tumorigenicity. In this report, again using the hybrid Ad5/12 E1A-transformants, we show that expression of these same two Ad12 E1A regions not only correlates with down-regulation of cell surface MHC class I expression, but coincides with the presence of an altered form of the E1A-associated cellular protein, p300, detected …