The overlapping burden of the three leading causes of disability and death in sub-Saharan African children Journal Articles uri icon

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abstract

  • AbstractDespite substantial declines since 2000, lower respiratory infections (LRIs), diarrhoeal diseases, and malaria remain among the leading causes of nonfatal and fatal disease burden for children under 5 years of age (under 5), primarily in sub-Saharan Africa (SSA). The spatial burden of each of these diseases has been estimated subnationally across SSA, yet no prior analyses have examined the pattern of their combined burden. Here we synthesise subnational estimates of the burden of LRIs, diarrhoea, and malaria in children under-5 from 2000 to 2017 for 43 sub-Saharan countries. Some units faced a relatively equal burden from each of the three diseases, while others had one or two dominant sources of unit-level burden, with no consistent pattern geographically across the entire subcontinent. Using a subnational counterfactual analysis, we show that nearly 300 million DALYs could have been averted since 2000 by raising all units to their national average. Our findings are directly relevant for decision-makers in determining which and targeting where the most appropriate interventions are for increasing child survival.

authors

  • Reiner, Robert C
  • Welgan, Catherine A
  • Troeger, Christopher E
  • Baumann, Mathew M
  • Weiss, Daniel J
  • Deshpande, Aniruddha
  • Blacker, Brigette F
  • Miller-Petrie, Molly K
  • Earl, Lucas
  • Bhatt, Samir
  • Abolhassani, Hassan
  • Abosetugn, Akine Eshete
  • Abu-Gharbieh, Eman
  • Adekanmbi, Victor
  • Adetokunboh, Olatunji O
  • Aghaali, Mohammad
  • Aji, Budi
  • Alahdab, Fares
  • Al-Aly, Ziyad
  • Alhassan, Robert Kaba
  • Ali, Saqib
  • Alizade, Hesam
  • Aljunid, Syed Mohamed
  • Almasi-Hashiani, Amir
  • Al-Mekhlafi, Hesham M
  • Altirkawi, Khalid A
  • Alvis-Guzman, Nelson
  • Amare, Azmeraw T
  • Amini, Saeed
  • Amugsi, Dickson A
  • Ancuceanu, Robert
  • Andrei, Catalina Liliana
  • Ansari, Fereshteh
  • Anvari, Davood
  • Appiah, Seth Christopher Yaw
  • Arabloo, Jalal
  • Aremu, Olatunde
  • Atout, Maha Moh’d Wahbi
  • Ausloos, Marcel
  • Ausloos, Floriane
  • Ayanore, Martin Amogre
  • Aynalem, Yared Asmare
  • Azene, Zelalem Nigussie
  • Badawi, Alaa
  • Baig, Atif Amin
  • Banach, Maciej
  • Bedi, Neeraj
  • Bhagavathula, Akshaya Srikanth
  • Bhandari, Dinesh
  • Bhardwaj, Nikha
  • Bhardwaj, Pankaj
  • Bhattacharyya, Krittika
  • Bhutta, Zulfiqar A
  • Bijani, Ali
  • Birhanu, Tesega Tesega Mengistu
  • Bitew, Zebenay Workneh
  • Boloor, Archith
  • Brady, Oliver J
  • Butt, Zahid A
  • Car, Josip
  • Carvalho, Felix
  • Casey, Daniel C
  • Chattu, Vijay Kumar
  • Chowdhury, Mohiuddin Ahsanul Kabir
  • Chu, Dinh-Toi
  • Coelho, Camila H
  • Cook, Aubrey J
  • Damiani, Giovanni
  • Daoud, Farah
  • Gela, Jiregna Darega
  • Darwish, Amira Hamed
  • Daryani, Ahmad
  • Das, Jai K
  • Davis Weaver, Nicole
  • Deribe, Kebede
  • Desalew, Assefa
  • Dharmaratne, Samath Dhamminda
  • Dianatinasab, Mostafa
  • Diaz, Daniel
  • Djalalinia, Shirin
  • Dorostkar, Fariba
  • Dubljanin, Eleonora
  • Duko, Bereket
  • Dwyer-Lindgren, Laura
  • Effiong, Andem
  • El Sayed Zaki, Maysaa
  • El Tantawi, Maha
  • Enany, Shymaa
  • Fattahi, Nazir
  • Feigin, Valery L
  • Fernandes, Eduarda
  • Ferrara, Pietro
  • Fischer, Florian
  • Foigt, Nataliya A
  • Folayan, Morenike Oluwatoyin
  • Foroutan, Masoud
  • Frostad, Joseph Jon
  • Fukumoto, Takeshi
  • Gaidhane, Abhay Motiramji
  • Gebrekrstos, Hailemikael Gebrekidan GK
  • Gebremeskel, Leake
  • Gebreslassie, Assefa Ayalew
  • Gething, Peter W
  • Gezae, Kebede Embaye
  • Ghadiri, Keyghobad
  • Ghashghaee, Ahmad
  • Golechha, Mahaveer
  • Gubari, Mohammed Ibrahim Mohialdeen
  • Hadgu, Fikaden Berhe
  • Hamidi, Samer
  • Handiso, Demelash Woldeyohannes
  • Hashi, Abdiwahab
  • Hassan, Shoaib
  • Hayat, Khezar
  • Herteliu, Claudiu
  • Ho, Hung Chak
  • Holla, Ramesh
  • Hosseinzadeh, Mehdi
  • Househ, Mowafa
  • Hussain, Rabia
  • Hwang, Bing-Fang
  • Ibitoye, Segun Emmanuel
  • Ilesanmi, Olayinka Stephen
  • Ilic, Irena M
  • Ilic, Milena D
  • Irvani, Seyed Sina Naghibi
  • Jaafari, Jalil
  • Javaheri, Tahereh
  • Jha, Ravi Prakash
  • Johnson, Kimberly B
  • Jonas, Jost B
  • Jozwiak, Jacek Jerzy
  • Kabir, Ali
  • Kalhor, Rohollah
  • Kanchan, Tanuj
  • Karch, André
  • Kayode, Gbenga A
  • Keiyoro, Peter Njenga
  • Khader, Yousef Saleh
  • Khalil, Ibrahim A
  • Khan, Md Nuruzzaman
  • Khan, Maseer
  • Khan, Gulfaraz
  • Khatab, Khaled
  • Khater, Mona M
  • Khatib, Mahalaqua Nazli
  • Kianipour, Neda
  • Kim, Yun Jin
  • Kimokoti, Ruth W
  • Kisa, Sezer
  • Kisa, Adnan
  • Kissoon, Niranjan
  • Kochhar, Sonali
  • Koolivand, Ali
  • Kopec, Jacek A
  • Koyanagi, Ai
  • Krishan, Kewal
  • Kumar, Pushpendra
  • Kurmi, Om P
  • Kusuma, Dian
  • Lal, Dharmesh Kumar
  • Lami, Faris Hasan
  • Landires, Iván
  • Lansingh, Van Charles
  • Lasrado, Savita
  • La Vecchia, Carlo
  • Lazzar-Atwood, Alice
  • Lee, Paul H
  • LeGrand, Kate E
  • Lewycka, Sonia
  • Li, Bingyu
  • Lim, Stephen S
  • Lindstedt, Paulina A
  • Liu, Xuefeng
  • Longbottom, Joshua
  • Lopez, Alan D
  • Magdy Abd El Razek, Hassan
  • Mahasha, Phetole Walter
  • Maleki, Afshin
  • Mamun, Abdullah A
  • Mansournia, Mohammad Ali
  • Marczak, Laurie B
  • Martins-Melo, Francisco Rogerlândio
  • Mayala, Benjamin K
  • Meharie, Birhanu Geta
  • Melese, Addisu
  • Mendoza, Walter
  • Menezes, Ritesh G
  • Mengesha, Endalkachew Worku
  • Mensah, George A
  • Meretoja, Tuomo J
  • Mestrovic, Tomislav
  • Miller, Ted R
  • Mirrakhimov, Erkin M
  • Moazen, Babak
  • Mohammad Gholi Mezerji, Naser
  • Mohammadi, Shadieh
  • Mohammed, Shafiu
  • Mokdad, Ali H
  • Moradi, Masoud
  • Moradzadeh, Rahmatollah
  • Moraga, Paula
  • Mosser, Jonathan F
  • Murray, Chrisopher JL
  • Naderi, Mehdi
  • Nagarajan, Ahamarshan Jayaraman
  • Nazari, Javad
  • Ndejjo, Rawlance
  • Negoi, Ionut
  • Ngunjiri, Josephine W
  • Nguyen, QuynhAnh P
  • Nguyen, Huong Lan Thi
  • Nnaji, Chukwudi A
  • Noubiap, Jean Jacques
  • Nuñez-Samudio, Virginia
  • Olagunju, Andrew
  • Olusanya, Jacob Olusegun
  • Olusanya, Bolajoko Olubukunola
  • Omer, Muktar Omer
  • Onwujekwe, Obinna E
  • Otstavnov, Nikita
  • Otstavnov, Stanislav S
  • Owolabi, Mayowa O
  • P A, Mahesh
  • Padubidri, Jagadish Rao
  • Pana, Adrian
  • Peprah, Emmanuel K
  • Pham, Hai Quang
  • Pigott, David M
  • Pirestani, Majid
  • Postma, Maarten J
  • Pottoo, Faheem Hyder
  • Pourjafar, Hadi
  • Quazi Syed, Zahiruddin
  • Rahim, Fakher
  • Rahimi-Movaghar, Vafa
  • Rahman, Mohammad Hifz Ur
  • Rao, Sowmya J
  • Rao, Puja C
  • Rathi, Priya
  • Rawaf, Salman
  • Rawaf, David Laith
  • Rawal, Lal
  • Rawassizadeh, Reza
  • Regassa, Lemma Demissie
  • Renzaho, Andre MN
  • Rezaei, Nima
  • Rezai, Mohammad Sadegh
  • Ribeiro, Ana Isabel
  • Rickard, Jennifer
  • Rios-González, Carlos Miguel
  • Rumisha, Susan Fred
  • Sabour, Siamak
  • Sajadi, S Mohammad
  • Salomon, Joshua A
  • Samadi Kafil, Hossein
  • Samy, Abdallah M
  • Sanabria, Juan
  • Sartorius, Benn
  • Saxena, Deepak
  • Schaeffer, Lauren E
  • Senthilkumaran, Subramanian
  • Sha, Feng
  • Shaheen, Amira A
  • Shaikh, Masood Ali
  • Sharma, Rajesh
  • Sheikh, Aziz
  • Shibuya, Kenji
  • Shigematsu, Mika
  • Il Shin, Jae
  • Simonetti, Biagio
  • Singh, Jasvinder A
  • Smith, David L
  • Soheili, Amin
  • Sokhan, Anton
  • Spurlock, Emma Elizabeth
  • Sreeramareddy, Chandrashekhar T
  • Sufiyan, Mu’awiyyah Babale
  • Swartz, Scott J
  • Tadesse, Degena Bahrey
  • Tamiru, Animut Tagele
  • Tefera, Yonas Getaye
  • Temsah, Mohamad-Hani
  • Tessema, Zemenu Tadesse
  • Titova, Mariya Vladimirovna
  • Tran, Bach Xuan
  • Truong, Phuong N
  • Unnikrishnan, Bhaskaran
  • Upadhyay, Era
  • Vasankari, Tommi Juhani
  • Vasseghian, Yasser
  • Violante, Francesco S
  • Vu, Giang Thu
  • Waheed, Yasir
  • Wamai, Richard G
  • Wassie, Emebet Gashaw
  • Welay, Fissaha Tekulu
  • Wickramasinghe, Nuwan Darshana
  • Wiens, Kirsten E
  • Wijeratne, Tissa
  • Wiysonge, Charles Shey
  • Wondmeneh, Temesgen Gebeyehu
  • Yamada, Tomohide
  • Yaya, Sanni
  • Yeshitila, Yordanos Gizachew
  • Yip, Paul
  • Yonemoto, Naohiro
  • Yu, Chuanhua
  • Yuce, Deniz
  • Yusefzadeh, Hasan
  • Zaidi, Zoubida
  • Zamanian, Maryam
  • Zangeneh, Alireza
  • Zhang, Zhi-Jiang
  • Zhang, Yunquan
  • Ziapour, Arash
  • Hay, Simon I

publication date

  • December 6, 2022