Enhanced binding and conformational selectivity in affinity capillary electrophoresis using a water‐soluble resorcin[4]arene as intrinsic buffer and electrokinetic host

Affinity capillary electrophoresis (ACE) is a widely used technique for quantifying non-covalent molecular interactions that is dependent on the specific buffer conditions selected. In this study, dynamic 1:1 host-guest inclusion complexation involving a charged resorcin[4]arene with a group of neutral corticosteroids was examined by ACE, where the macrocycle serves as both an intrinsic buffer and electrokinetic host. It was determined that …