iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections Academic Article uri icon

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abstract

  • The Amaryllidaceae alkaloid trans-dihydrolycoricidine 7 and three analogues 8-10 were produced via asymmetric chemical synthesis. Alkaloid 7 proved superior to acyclovir, the current standard for herpes simplex virus, type 1 (HSV-1) infection. Compound 7 potently inhibited lytic HSV-1 infection, significantly reduced HSV-1 reactivation, and more potently inhibited varicella zoster virus (VZV) lytic infection. A configurationally defined (3R)-secondary alcohol at C3 proved crucial for efficacious inhibition of lytic HSV-1 infection.

authors

  • Mcnulty, James
  • D’Aiuto, Leonardo
  • Zhi, Yun
  • McClain, Lora
  • Zepeda-Velázquez, Carlos
  • Ler, Spencer
  • Jenkins, Hilary A
  • Yee, Michael B
  • Piazza, Paolo
  • Yolken, Robert H
  • Kinchington, Paul R
  • Nimgaonkar, Vishwajit L

publication date

  • January 14, 2016