Journal article
Novel Class of Tertiary Phosphine Ligands Based on a Phospha-adamantane Framework and Use in the Suzuki Cross-Coupling Reactions of Aryl Halides under Mild Conditions
Abstract
[reaction: see text] A new class of sterically hindered phosphines based on a phospha-adamantane framework is described. Arylation or alkylation of the 1,3,5,7-tetramethyl-2,4,8-trioxa-6-phospha-adamantane system allows for the preparation of tertiary phosphines suitable for use in palladium-catalyzed cross-coupling reactions. For example, use of a catalytic system incorporating Pd(2)(dba)(3) and …
Authors
Adjabeng G; Brenstrum T; Wilson J; Frampton C; Robertson A; Hillhouse J; McNulty J; Capretta A
Journal
Organic Letters, Vol. 5, No. 6, pp. 953–955
Publisher
American Chemical Society (ACS)
Publication Date
March 1, 2003
DOI
10.1021/ol0341647
ISSN
1523-7060