Ibogaine Interferes with the Establishment of Conditioned Taste Avoidance Produced by Morphine and Lithium

Ibogaine, a putative anti-craving drug, attenuated the establishment of both morphine-induced and lithium-induced conditioned taste avoidance when administered 22 h prior to the conditioning trial. The attenuated avoidance was not the result of nonspecific drug preexposure, because a single exposure to a high dose of morphine or lithium chloride 22 h prior to a conditioning trial did not interfere with morphine-induced taste avoidance. The results suggest that ibogaine interferes with conditioned taste avoidance learning.