Cardiovascular profile in postural orthostatic tachycardia syndrome and Ehlers–Danlos syndrome type III

The cardiovascular profile of postural orthostatic tachycardia syndrome + Ehlers–Danlos syndrome hypermobility type (POTS + EDSIII) has not been described, despite suggestions that it plays a role in orthostatic intolerance. We studied nine individuals diagnosed with POTS + EDSIII and found that the arterial stiffness and cardiac profiles of patients with POTS + EDSIII were comparable to those of age- and sex-matched controls, suggesting an alternate explanation for orthostatic intolerance.