Journal article
A convenient solution-phase method for the preparation of meta-iodobenzylguanidine in high effective specific activity
Abstract
INTRODUCTION: There is a need for new methods of producing receptor-targeted molecular radioimaging and radiotherapy agents in high effective specific activity. This is particularly true for targets that are expressed in relatively low concentrations.
METHODS: A highly fluorinated (fluorous) tin precursor of meta-iodobenzylguanidine (MIBG) was prepared, such that upon labeling, the desired product was formed with concomitant release of the …
Authors
Donovan AC; Valliant JF
Journal
Nuclear Medicine and Biology, Vol. 35, No. 7, pp. 741–746
Publisher
Elsevier
Publication Date
10 2008
DOI
10.1016/j.nucmedbio.2008.07.006
ISSN
0969-8051