Journal article
Preparation and evaluation of carborane-derived inhibitors of prostate specific membrane antigen (PSMA)
Abstract
A series of C-hydroxy carborane derivatives of (S)-2-(3-((S)-5-amino-1-carboxypentyl)ureido)-pentanedioic acid were prepared as a new class of boron rich inhibitors of prostate specific membrane antigen (PSMA), which is overexpressed on prostate cancer tumours and metastases. Closo-, nido- and iodo-carborane conjugates were prepared and screened in vitro where the water soluble iodinated cluster had the highest affinity with an IC50 value (73.2 …
Authors
El-Zaria ME; Genady AR; Janzen N; Petlura CI; Vera DRB; Valliant JF
Journal
Dalton Transactions, Vol. 43, No. 13, pp. 4950–4961
Publisher
Royal Society of Chemistry (RSC)
Publication Date
April 7, 2014
DOI
10.1039/c3dt53189a
ISSN
1477-9226