Journal article
The accessory subunit of DNA polymerase γ is essential for mitochondrial DNA maintenance and development in Drosophila melanogaster
Abstract
DNA polymerase gamma, Pol gamma, is the key replicative enzyme in animal mitochondria. The Drosophila enzyme is a heterodimer comprising catalytic and accessory subunits of 125 kDa and 35 kDa, respectively. Both subunits have been cloned and characterized in a variety of model systems, and genetic mutants of the catalytic subunit were first identified in Drosophila, as chemically induced mutations that disrupt larval behavior (tamas). Mutations …
Authors
Iyengar B; Luo N; Farr CL; Kaguni LS; Campos AR
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, No. 7, pp. 4483–4488
Publisher
Proceedings of the National Academy of Sciences
Publication Date
April 2, 2002
DOI
10.1073/pnas.072664899
ISSN
0027-8424