Journal article
Covalently closed circles of human adenovirus DNA are infectious.
Abstract
Replication of the linear adenovirus DNA molecule is thought to result from semiconservative synthesis off linear templates, starting from origins at either end of the genome. Recently, however, it has been shown that in cells infected with adenovirus type 5 (Ad5) a significant fraction of the ends of viral DNA molecules become joined head‐to‐tail due at least in part to the formation of covalently closed circles. Circular DNA is not present in …
Authors
Graham FL
Journal
The EMBO Journal, Vol. 3, No. 12, pp. 2917–2922
Publisher
Springer Nature
Publication Date
12 1984
DOI
10.1002/j.1460-2075.1984.tb02232.x
ISSN
0261-4189