Understanding pulse oximetry in hematology patients: Hemoglobinopathies, racial differences, and beyond

Pulse oximetry (SpO₂ ) is a widely used, non-invasive method of estimating arterial oxygen saturation. Measurement of SpO₂ relies on comparing the relative absorption of light in the red and infrared regions with the expected absorption pattern of oxygenated and deoxygenation adult hemoglobin. As this screening tool has entered common clinical use, test limitations have emerged, including concern about the risk of overestimation of oxygen …