Journal article
Neuronal fusion pore assembly requires membrane cholesterol
Abstract
Cholesterol has been proposed to play a critical role in regulating neurotransmitter release and synaptic plasticity. The neuronal porosome/fusion pore, the secretory machinery at the nerve terminal, is a 12-17 nm cup-shaped lipoprotein structure composed of cholesterol and a number of proteins, among them calcium channels, and the t-SNARE proteins Syntaxin-1 and SNAP-25. During neurotransmission, synaptic vesicles dock and fuse at the porosome …
Authors
Cho WJ; Jeremic A; Jin H; Ren G; Jena BP
Journal
Cell Biology International, Vol. 31, No. 11, pp. 1301–1308
Publisher
Wiley
Publication Date
November 2007
DOI
10.1016/j.cellbi.2007.06.011
ISSN
1065-6995