Journal article
Ligustrazine prevents coronary microcirculation dysfunction in rats via suppression of miR-34a-5p and promotion of Sirt1
Abstract
INTRODUCTION: The coronary microembolization contributes to coronary microvascular dysfunction (CMD), in which miR-34a-5p may play a critical role. Ligustrazine has been reported to improve CMD. The present study was designed to discuss the role of miR-34a-5p/Sirt1 pathway in CMD and explore the underlying mechanism of ligustrazine.
METHODS: Coronary microembolization (CME) was induced by left ventricle injection of sodium laurate in rats. CME …
Authors
Gao J; Ren J; Ma X; Zhang Y; Song L; Liu J; Shi D; Ma X
Journal
European Journal of Pharmacology, Vol. 929, ,
Publisher
Elsevier
Publication Date
August 2022
DOI
10.1016/j.ejphar.2022.175150
ISSN
0014-2999