Journal article
Modulation of tolerance to the lethal effect of morphine by extinction
Abstract
In contrast with previous demonstrations that tolerance to the analgesic and thermic effects of morphine can be extinguished by repeated placebo administrations, Sklar and Amit (1978, Behavioral Biology, 22, 509–514) purportedly demonstrated that tolerance to morphine-induced mortality is not affected by such an extinction procedure. The results of the present experiment demonstrated that rats administered a fatal dose of morphine following a …
Authors
Siegel S; Hinson RE; Krank MD
Journal
Behavioral and Neural Biology, Vol. 25, No. 2, pp. 257–262
Publisher
Elsevier
Publication Date
February 1979
DOI
10.1016/s0163-1047(79)90610-1
ISSN
0163-1047