The role of Pavlovian processes in drug tolerance and dependence: Implications for treatment

Evidence for the crucial role of Pavlovian conditional compensatory responses in tolerance to opiates and alcohol is presented. Furthermore, an analysis of the motivational role of Pavlovian conditional compensatory responses to craving and relapse is discussed, and supportive experimental and epidemiological evidence are presented. Given the role ascribed to Pavlovian processes in tolerance, craving, and relapse, it is proposed that extinction …