Attenuation of ethanol tolerance by a novel stimulus Journal Articles

abstract

• A Pavlovian conditioning model of tolerance emphasizes that an association between predrug cues and the systemic effects of the drug contributes to tolerance. On the basis of this model, established tolerance should be attenuated by "external inhibition," i.e., by presentation of a novel, extraneous stimulus. This prediction was evaluated in the present experiment. Rats that were so tolerant to the hypothermic effect of ethanol that they evidenced no drug-induced decrease in temperature were presented with a bright strobe light following ethanol administration. The light precipitated a large decrease in temperature in these rats. These results provide further evidence that tolerance to the hypothermic effect of ethanol is, in part, mediated by learning.

authors

• Siegel, Shepard
• Sdao-Jarvie, Katherine

status

• published 

publication date

• 1986

has subject area

• 11 Medical and Health Sciences (FoR)
• 17 Psychology and Cognitive Sciences (FoR)
• Animals (MeSH)
• Body Temperature (MeSH)
• Conditioning, Classical (MeSH)
• Cues (MeSH)
• Drug Tolerance (MeSH)
• Environment (MeSH)
• Ethanol (MeSH)
• Inhibition, Psychological (MeSH)
• Male (MeSH)
• Models, Psychological (MeSH)
• Photic Stimulation (MeSH)
• Psychiatry (Science Metrix)
• Rats (MeSH)
• Rats, Inbred Strains (MeSH)

published in

• Psychopharmacology  Journal

keywords

• Animals
• Body Temperature
• Conditioning, Classical
• Cues
• Drug Tolerance
• Environment
• Ethanol
• Inhibition, Psychological
• Male
• Models, Psychological
• Photic Stimulation
• Rats
• Rats, Inbred Strains

Digital Object Identifier (DOI)

• 10.1007/bf00652251

PubMed ID

• 3081936

start page

• 258

end page

• 261

volume

• 88

issue

• 2