Journal article
Extinction of Tolerance to the Analgesic Effect of Morphine: Intracerebroventricular Administration and Effects of Stress
Abstract
Previous research demonstrated that tolerance to the analgesic effect of morphine in rats is attenuated by administrations of a placebo in the context of drug-associated cues. Such apparent extinction of tolerance has been interpreted as support for a Pavlovian conditioning model of tolerance. Recently, it has been suggested that these findings are attributable to stress, induced during placebo sessions and augmenting the analgesic effect of …
Authors
MacRae JR; Siegel S
Journal
Behavioral Neuroscience, Vol. 101, No. 6, pp. 790–796
Publisher
American Psychological Association (APA)
Publication Date
December 1987
DOI
10.1037/0735-7044.101.6.790
ISSN
0735-7044